Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid accumulation and fibrotic change accompanying inflammation. Indeed, Pin1-deficient mice are highly resi...

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發表在:Cells
Main Authors: Inoue, Masa-Ki, Nakatsu, Yusuke, Yamamotoya, Takeshi, Hasei, Shun, Kanamoto, Mayu, Naitou, Miki, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro
格式: Artigo
語言:Inglês
出版: MDPI 2019
主題:
Review
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952946/
https://ncbi.nlm.nih.gov/pubmed/31795496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121545
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