The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion

The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion. This report is the first to show that Pin1 expression in pancreatic β cells is markedly elevated by high-fat diet feeding and in ob/ob mice. To elucidate the role of Pi...

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Vydáno v:J Biol Chem
Hlavní autoři: Nakatsu, Yusuke, Mori, Keiichi, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Yuki, Mitsuzaki-Miyoshi, Keiko, Sakoda, Hideyuki, Fujishiro, Midori, Yamaguchi, Suguru, Kushiyama, Akifumi, Ono, Hiraku, Ishihara, Hisamitsu, Asano, Tomoichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512081/
https://ncbi.nlm.nih.gov/pubmed/28566287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780726
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