AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

AMP-activated protein kinase (AMPK) activation reportedly suppresses transcriptional activity of the cAMP-responsive element (CRE) in the phosphoenolpyruvate carboxykinase C (PEPCK-C) promoter and reduces hepatic PEPCK-C expression. Although a previous study found TORC2 phosphorylation to be involve...

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Detalhes bibliográficos
Main Authors: Horike, Nanao, Sakoda, Hideyuki, Kushiyama, Akifumi, Ono, Hiraku, Fujishiro, Midori, Kamata, Hideaki, Nishiyama, Koichi, Uchijima, Yasunobu, Kurihara, Yukiko, Kurihara, Hiroki, Asano, Tomoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662216/
https://ncbi.nlm.nih.gov/pubmed/18801732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802537200
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