Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

Sirtuins are a phylogenetically conserved NAD(+)-dependent protein deacetylase/ADP-ribosyltransferase family implicated in diverse biological processes. Several family members localize to mitochondria, the function of which is thought to determine the developmental potential of preimplantation embry...

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Autors principals: Kawamura, Yumiko, Uchijima, Yasunobu, Horike, Nanao, Tonami, Kazuo, Nishiyama, Koichi, Amano, Tomokazu, Asano, Tomoichiro, Kurihara, Yukiko, Kurihara, Hiroki
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912189/
https://ncbi.nlm.nih.gov/pubmed/20644252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42020
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