Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity

Pin1 is a unique regulator, which catalyzes the conversion of a specific phospho-Ser/Thr-Pro-containing motif in target proteins. Herein, we identified CRTC2 as a Pin1-binding protein by overexpressing Pin1 with Myc and FLAG tags in mouse livers and subsequent purification of the complex containing...

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Detalhes bibliográficos
Main Authors: Nakatsu, Yusuke, Sakoda, Hideyuki, Kushiyama, Akifumi, Ono, Hiraku, Fujishiro, Midori, Horike, Nanao, Yoneda, Masayasu, Ohno, Haruya, Tsuchiya, Yoshihiro, Kamata, Hideaki, Tahara, Hidetoshi, Isobe, Toshiaki, Nishimura, Fusanori, Katagiri, Hideki, Oka, Yoshitomo, Fukushima, Toshiaki, Takahashi, Shin-Ichiro, Kurihara, Hiroki, Uchida, Takafumi, Asano, Tomoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963389/
https://ncbi.nlm.nih.gov/pubmed/20675384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.137836
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