Structural Mechanisms of Peptide Recognition and Allosteric Modulation of Gene Regulation by the RRNPP-Family of Quorum-Sensing Regulators

Por Do, Hackwon, Kumaraswami, Muthiah
Publicado no J Mol Biol (2016)

Zinc’ing it out: Zinc homeostasis mechanisms and their impact on the pathogenesis of human pathogen group A streptococcus

Por Makthal, Nishanth, Kumaraswami, Muthiah
Publicado no Metallomics (2017)

Conformational plasticity of the coiled coil domain of BmrR is required for bmr operator binding - the structure of unliganded BmrR

Por Kumaraswami, Muthiah, Newberry, Kate J., Brennan, Richard G.
Publicado em 2010

Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition

Por Ni, Lisheng, Xu, Weijun, Kumaraswami, Muthiah, Schumacher, Maria A.
Publicado em 2010

The FasX Small Regulatory RNA Negatively Regulates the Expression of Two Fibronectin-Binding Proteins in Group A Streptococcus

Por Danger, Jessica L., Makthal, Nishanth, Kumaraswami, Muthiah, Sumby, Paul
Publicado no J Bacteriol (2015)

Multimerization of the Virulence-Enhancing Group A Streptococcus Transcription Factor RivR Is Required for Regulatory Activity

Por Ramalinga, Anupama, Danger, Jessica L., Makthal, Nishanth, Kumaraswami, Muthiah, Sumby, Paul
Publicado no J Bacteriol (2016)

Genetic Analysis of Phage Mu Mor Protein Amino Acids Involved in DNA Minor Groove Binding and Conformational Changes

Por Kumaraswami, Muthiah, Avanigadda, Lakshmi, Rai, Rajendra, Park, Hee-Won, Howe, Martha M.
Publicado em 2011

Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA

Por Kumaraswami, Muthiah, Schuman, Jason T., Seo, Susan M., Kaatz, Glenn W., Brennan, Richard G.
Publicado em 2009

Structural and functional analysis of RopB: a major virulence regulator in S treptococcus pyogenes

Por Makthal, Nishanth, Gavagan, Maire, Do, Hackwon, Olsen, Randall J., Musser, James M., Kumaraswami, Muthiah
Publicado no Mol Microbiol (2016)

Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence

Por Sanson, Misu, Makthal, Nishanth, Flores, Anthony R., Olsen, Randall J., Musser, James M., Kumaraswami, Muthiah
Publicado no Nucleic Acids Res (2015)

Phosphorylation Events in the Multiple Gene Regulator of Group A Streptococcus Significantly Influence Global Gene Expression and Virulence

Por Sanson, Misu, Makthal, Nishanth, Gavagan, Maire, Cantu, Concepcion, Olsen, Randall J., Musser, James M., Kumaraswami, Muthiah
Publicado no Infect Immun (2015)

Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth Ex Vivo and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus

Por Makthal, Nishanth, Do, Hackwon, VanderWal, Arica R., Olsen, Randall J., Musser, James M., Kumaraswami, Muthiah
Publicado no Infect Immun (2018)

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence

Por VanderWal, Arica R., Makthal, Nishanth, Pinochet-Barros, Azul, Helmann, John D., Olsen, Randall J., Kumaraswami, Muthiah
Publicado no Infect Immun (2017)

Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence

Por Do, Hackwon, Makthal, Nishanth, Chandrangsu, Pete, Olsen, Randall J, Helmann, John D, Musser, James M, Kumaraswami, Muthiah
Publicado no Nucleic Acids Res (2019)

Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence

Por Do, Hackwon, Makthal, Nishanth, Chandrangsu, Pete, Olsen, Randall J, Helmann, John D, Musser, James M, Kumaraswami, Muthiah
Publicado no Nucleic Acids Res (2019)

A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development

Por Makthal, Nishanth, Nguyen, Kimberly, Do, Hackwon, Gavagan, Maire, Chandrangsu, Pete, Helmann, John D., Olsen, Randall J., Kumaraswami, Muthiah
Publicado no EBioMedicine (2017)

Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence

Por Makthal, Nishanth, Do, Hackwon, Wendel, Brian M., Olsen, Randall J., Helmann, John D., Musser, James M., Kumaraswami, Muthiah
Publicado no Infect Immun (2020)

Crystal Structure of Peroxide Stress Regulator from Streptococcus pyogenes Provides Functional Insights into the Mechanism of Oxidative Stress Sensing

Por Makthal, Nishanth, Rastegari, Sheila, Sanson, Misu, Ma, Zhen, Olsen, Randall J., Helmann, John D., Musser, James M., Kumaraswami, Muthiah
Publicado em 2013

Functional Consequences of Substitution Mutations in MepR, a Repressor of the Staphylococcus aureus mepA Multidrug Efflux Pump Gene

Por Schindler, Bryan D., Seo, Susan M., Jacinto, Pauline L., Kumaraswami, Muthiah, Birukou, Ivan, Brennan, Richard G., Kaatz, Glenn W.
Publicado em 2013

Natural Variation in the Promoter of the Gene Encoding the Mga Regulator Alters Host-Pathogen Interactions in Group A Streptococcus Carrier Strains

Por Flores, Anthony R., Olsen, Randall J., Wunsche, Andrea, Kumaraswami, Muthiah, Shelburne, Samuel A., Carroll, Ronan K., Musser, James M.
Publicado em 2013