Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence

Group A Streptococcus (GAS) is a human-only pathogen that causes a spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense and overcome oxidative stress is critical for GAS pathogenesis. PerR senses oxidative stress and coordinates the regulation of genes involve...

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Bibliographic Details
Published in:Infect Immun
Main Authors: VanderWal, Arica R., Makthal, Nishanth, Pinochet-Barros, Azul, Helmann, John D., Olsen, Randall J., Kumaraswami, Muthiah
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442632/
https://ncbi.nlm.nih.gov/pubmed/28348051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00091-17
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