PRECLINICAL MODELS OF NONALCOHOLIC FATTY LIVER DISEASE

Por Santhekadur, Prasanna K., Kumar, Divya P., Sanyal, Arun J.
Publicado no J Hepatol (2017)

Inhibition of Gα(i) activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gα(i) and recruitment of RGS12

Por Huang, Jiean, Nalli, Ancy D., Mahavadi, Sunila, Kumar, Divya P., Murthy, Karnam S.
Publicado em 2014

The multifaceted role of natriuretic peptides in metabolic syndrome

Por Santhekadur, Prasanna K., Kumar, Divya P., Seneshaw, Mulugeta, Mirshahi, Faridoddin, Sanyal, Arun J.
Publicado no Biomed Pharmacother (2017)

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

Por Kumar, Divya P., Rajagopal, Senthilkumar, Mahavadi, Sunila, Mirshahi, Faridoddin, Grider, John R., Murthy, Karnam S., Sanyal, Arun J.
Publicado em 2012

Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle

Por Mahavadi, Sunila, Nalli, Ancy D., Kumar, Divya P., Hu, Wenhui, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Publicado em 2014

Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1(−/−) mice impair the peristaltic reflex and propulsion

Por Mahavadi, Sunila, Bhattacharya, Sayak, Kumar, Divya P., Clay, Chereena, Ross, Gracious, Akbarali, Hamid I., Grider, John R., Murthy, Karnam S.
Publicado em 2013

Regulation of Gβγ(i)-dependent PLC-β3 Activity in Smooth Muscle: Inhibitory Phosphorylation of PLC-β3 by PKA and PKG and Stimulatory Phosphorylation of Gα(i)-GTPase Activating Prot...

Por Nalli, Ancy D., Kumar, Divya P., Al-Shboul, Othman, Mahavadi, Sunila, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Publicado em 2014

Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation

Por Rajagopal, Senthilkumar, Nalli, Ancy D., Kumar, Divya P., Bhattacharya, Sayak, Hu, Wenhui, Mahavadi, Sunila, Grider, John R., Murthy, Karnam S.
Publicado no J Pharmacol Exp Ther (2015)

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H(2)S

Por Bala, Vanitha, Rajagopal, Senthilkumar, Kumar, Divya P., Nalli, Ancy D., Mahavadi, Sunila, Sanyal, Arun J., Grider, John R., Murthy, Karnam S.
Publicado em 2014

Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation

Por Al-Shboul, Othman, Nalli, Ancy D., Kumar, Divya P., Zhou, Ruizhe, Mahavadi, Sunila, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Publicado em 2014

Hypercontractility of Intestinal Longitudinal Smooth Muscle Induced by Cytokines Is Mediated by the Nuclear Factor-κB/AMP-Activated Kinase/Myosin Light Chain Kinase Pathway

Por Nalli, Ancy D., Kumar, Divya P., Mahavadi, Sunila, Al-Shboul, Othman, Alkahtani, Reem, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Publicado em 2014

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

Por Rajagopal, Senthilkumar, Kumar, Divya P., Mahavadi, Sunila, Bhattacharya, Sayak, Zhou, Ruizhe, Corvera, Carlos U., Bunnett, Nigel W., Grider, John R., Murthy, Karnam S.
Publicado em 2013

Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

Por Kumar, Divya P., Asgharpour, Amon, Mirshahi, Faridoddin, Park, So Hyun, Liu, Sichen, Imai, Yumi, Nadler, Jerry L., Grider, John R., Murthy, Karnam S., Sanyal, Arun J.
Publicado no J Biol Chem (2016)

THE PRESENCE AND SEVERITY OF NONALCOHOLIC STEATOHEPATITIS IS ASSOCIATED WITH SPECIFIC CHANGES IN CIRCULATING BILE ACIDS

Por Puri, Puneet, Daita, Kalyani, Joyce, Andrew, Mirshahi, Faridoddin, Santhekadur, Prasanna K., Cazanave, Sophie, Luketic, Velimir A, Siddiqui, Mohammad S., Boyett, Sherry, Min, Hae-Ki, Kumar, Divya P., Kohli, Rohit, Zhou, Huiping, Hylemon, Phillip B., Contos, Melissa J, Idowu, Michael, Sanyal, Arun J.
Publicado no Hepatology (2017)

THE CIRCULATING MICROBIOME SIGNATURE AND INFERRED FUNCTIONAL METAGENOMICS IN ALCOHOLIC HEPATITIS

Por Puri, Puneet, Liangpunsakul, Suthat, Christensen, Jeffrey E., Shah, Vijay H., Kamath, Patrick S., Gores, Gregory J., Walker, Susan, Comerford, Megan, Katz, Barry, Borst, Andrew, Yu, Qigui, Kumar, Divya P., Mirshahi, Faridoddin, Radaeva, Svetlana, Chalasani, Naga P., Crabb, David W., Sanyal, Arun J.
Publicado no Hepatology (2018)

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease

Por Cazanave, Sophie, Podtelezhnikov, Alexei, Jensen, Kristian, Seneshaw, Mulugeta, Kumar, Divya P., Min, Hae-Ki, Santhekadur, Prasanna K., Banini, Bubu, Mauro, Adolfo Gabriele, M. Oseini, Abdul, Vincent, Robert, Tanis, Keith Q., Webber, Andrea L., Wang, Liangsu, Bedossa, Pierre, Mirshahi, Faridoddin, Sanyal, Arun J.
Publicado no Sci Rep (2017)