Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

The present study characterized the TGR5 expression and the signaling pathways coupled to this receptor that mediates the relaxation of gastric smooth muscle. TGR5 was detected in gastric muscle cells by RT-PCR and Western blotting. Treatment of cells with the TGR5-selective ligand oleanolic acid (O...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Rajagopal, Senthilkumar, Kumar, Divya P., Mahavadi, Sunila, Bhattacharya, Sayak, Zhou, Ruizhe, Corvera, Carlos U., Bunnett, Nigel W., Grider, John R., Murthy, Karnam S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602680/
https://ncbi.nlm.nih.gov/pubmed/23275618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00388.2012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados