Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1(−/−) mice impair the peristaltic reflex and propulsion

Caveolae are specialized regions of the plasma membrane that concentrate receptors and associated signaling molecules critical in regulation of cellular response to transmitters and hormones. We have determined the effects of caveolin-1 (Cav-1) deletion, caveolin-1 siRNA, and caveolar disruption in...

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Detalhes bibliográficos
Main Authors: Mahavadi, Sunila, Bhattacharya, Sayak, Kumar, Divya P., Clay, Chereena, Ross, Gracious, Akbarali, Hamid I., Grider, John R., Murthy, Karnam S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882438/
https://ncbi.nlm.nih.gov/pubmed/24157969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00165.2013
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