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Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
Bile acids act as signaling molecules and stimulate the G protein coupled receptor, TGR5, in addition to nuclear farnesoid X receptor to regulate lipid, glucose and energy metabolism. Bile acid induced activation of TGR5 in the enteroendocrine cells promotes glucagon like peptide-1 (GLP-1) release,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3498511/ https://ncbi.nlm.nih.gov/pubmed/23022524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.09.104 |
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