Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

Bile acids act as signaling molecules and stimulate the G protein coupled receptor, TGR5, in addition to nuclear farnesoid X receptor to regulate lipid, glucose and energy metabolism. Bile acid induced activation of TGR5 in the enteroendocrine cells promotes glucagon like peptide-1 (GLP-1) release,...

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Autores principales: Kumar, Divya P., Rajagopal, Senthilkumar, Mahavadi, Sunila, Mirshahi, Faridoddin, Grider, John R., Murthy, Karnam S., Sanyal, Arun J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498511/
https://ncbi.nlm.nih.gov/pubmed/23022524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.09.104
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