Regulation of Gβγ(i)-dependent PLC-β3 Activity in Smooth Muscle: Inhibitory Phosphorylation of PLC-β3 by PKA and PKG and Stimulatory Phosphorylation of Gα(i)-GTPase Activating Protein RGS2 by PKG

In gastrointestinal smooth muscle, agonists that bind to G(i)-coupled receptors activate preferentially PLC-β3 via Gβγ to stimulate phosphoinositide (PI) hydrolysis and generate inositol 1,4,5-trisphosphate (IP(3)) leading to IP(3)-dependent Ca(2+) release and muscle contraction. In the present stud...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nalli, Ancy D., Kumar, Divya P., Al-Shboul, Othman, Mahavadi, Sunila, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184950/
https://ncbi.nlm.nih.gov/pubmed/24777815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12013-014-9992-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados