Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle

This study identified a distinctive pattern of expression and activity of adenylyl cyclase (AC) and phosphodiesterase (PDE) isoforms in mouse colonic longitudinal smooth muscle cells and determined the changes in their expression and/or activity in response to proinflammatory cytokines (IL-1β and TN...

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Bibliographic Details
Main Authors: Mahavadi, Sunila, Nalli, Ancy D., Kumar, Divya P., Hu, Wenhui, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137135/
https://ncbi.nlm.nih.gov/pubmed/24944202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00123.2014
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