Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation

The effect of proinflammatory cytokines on the expression and activity of soluble guanylyl cyclase (sGC) and cGMP–phosphodiesterases (PDEs) was determined in intestinal longitudinal smooth muscle. In control muscle cells, cGMP levels are regulated via activation of sGC and PDE5; the activity of the...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Rajagopal, Senthilkumar, Nalli, Ancy D., Kumar, Divya P., Bhattacharya, Sayak, Hu, Wenhui, Mahavadi, Sunila, Grider, John R., Murthy, Karnam S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352595/
https://ncbi.nlm.nih.gov/pubmed/25550199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221929
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