Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation

The effect of proinflammatory cytokines on the expression and activity of soluble guanylyl cyclase (sGC) and cGMP–phosphodiesterases (PDEs) was determined in intestinal longitudinal smooth muscle. In control muscle cells, cGMP levels are regulated via activation of sGC and PDE5; the activity of the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Rajagopal, Senthilkumar, Nalli, Ancy D., Kumar, Divya P., Bhattacharya, Sayak, Hu, Wenhui, Mahavadi, Sunila, Grider, John R., Murthy, Karnam S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2015
Pynciau:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352595/
https://ncbi.nlm.nih.gov/pubmed/25550199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221929
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