Inhibitory signaling by CB(1) receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinase

We examined whether CB(1) receptors in smooth muscle conform to the signaling pattern observed with other G(i)-coupled receptors that stimulate contraction via two Gβγ-dependent pathways (PLC-β3 and phosphatidylinositol 3-kinase/integrin-linked kinase). Here we show that the anticipated Gβγ-dependen...

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Bibliographic Details
Main Authors: Mahavadi, Sunila, Sriwai, Wimolpak, Huang, Jiean, Grider, John R., Murthy, Karnam S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Hormones and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949025/
https://ncbi.nlm.nih.gov/pubmed/24407588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00397.2013
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