Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity

по Ghag, Gaurav, Holler, Christopher J., Taylor, Georgia, Kukar, Thomas L., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Опубликовано в: Protein Sci (2017)

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

по Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Опубликовано в: Biochemistry (2009)

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

по Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.
Опубликовано 2011

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

по Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Опубликовано 2014

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND...

по Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Опубликовано 2011

Short Aβ peptides attenuate Aβ42 toxicity in vivo

по Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Опубликовано в: J Exp Med (2018)

Substrate-targeting γ-secretase modulators

по Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Опубликовано 2008