Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity

par Ghag, Gaurav, Holler, Christopher J., Taylor, Georgia, Kukar, Thomas L., Uversky, Vladimir N., Rangachari, Vijayaraghavan
Publié dans Protein Sci (2017)

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1()

par Frigerio, Carlo Sala, Kukar, Thomas L., Fauq, Abdul, Engel, Paul C., Golde, Todd E., Walsh, Dominic M.
Publié dans Biochemistry (2009)

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

par Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.
Publié 2011

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

par Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publié 2014

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND...

par Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Publié 2011

Short Aβ peptides attenuate Aβ42 toxicity in vivo

par Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Publié dans J Exp Med (2018)

Substrate-targeting γ-secretase modulators

par Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Publié 2008