Chronic Exposure to Rifaximin Causes Hepatic Steatosis in Pregnane X Receptor-Humanized Mice

Por Cheng, Jie, Krausz, Kristopher W., Tanaka, Naoki, Gonzalez, Frank, J.
Publicado em 2012

IDENTIFICATION OF NOVEL TOXICITY-ASSOCIATED METABOLITES BY METABOLOMICS AND MASS ISOTOPOMER ANALYSIS OF ACETAMINOPHEN METABOLISM IN WILD-TYPE AND CYP2E1-NULL MICE

Por Chen, Chi, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2007

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology

Por Soars, Matthew G, Gelboin, Harry V, Krausz, Kristopher W, Riley, Robert J
Publicado em 2003

Metabolomics Identifies Novel Hnf1α-Dependent Physiological Pathways in Vivo

Por Bonzo, Jessica A., Patterson, Andrew D., Krausz, Kristopher W., Gonzalez, Frank J.
Publicado em 2010

Pregnane X receptor-mediated induction of Cyp3a by black cohosh

Por Pang, Xiaoyan, Cheng, Jie, Krausz, Kristopher W., Guo, De-an, Gonzalez, Frank J.
Publicado em 2010

CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid

Por Cheng, Jie, Krausz, Kristopher W., Li, Feng, Ma, Xiaochao, Gonzalez, Frank J.
Publicado em 2012

Metabolomic and Genetic Analysis of Biomarkers for PPARα Expression and Activation

Por Zhen, Yueying, Krausz, Kristopher W., Chen, Chi, Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2007

Role of Pregnane X Receptor in Control of All-Trans Retinoic Acid (ATRA) Metabolism and Its Potential Contribution to ATRA Resistance

Por Wang, Ting, Ma, Xiaochao, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2007

A Metabolomic Perspective of Melatonin Metabolism in the Mouse

Por Ma, Xiaochao, Chen, Chi, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2008

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

Por Cheng, Jie, Ma, Xiaochao, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2009

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis

Por Li, Fei, Patterson, Andrew D., Krausz, Kristopher W., Tanaka, Naoki, Gonzalez, Frank J.
Publicado em 2012

Disruption of Phospholipid and Bile Acid Homeostasis in Mice With Nonalcoholic Steatohepatitis

Por Tanaka, Naoki, Matsubara, Tsutomu, Krausz, Kristopher W., Patterson, Andrew D., Gonzalez, Frank J.
Publicado no Hepatology (2012)

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-induced Hepato...

Por Chen, Chi, Krausz, Kristopher W., Shah, Yatrik M., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2009

PPARα-dependent Induction of Uncoupling Protein 2 Protects Against Acetaminophen-Induced Liver Toxicity

Por Patterson, Andrew D., Shah, Yatrik M., Matsubara, Tsutomu, Krausz, Kristopher W., Gonzalez, Frank J.
Publicado em 2012

A Metabolomic Approach to the Metabolism of the Areca Nut Alkaloids Arecoline and Aracaidine in the Mouse

Por Giri, Sarbani, Idle, Jeffrey R., Chen, Chi, Zabriskie, T. Mark, Krausz, Kristopher W., Gonzalez, Frank J.
Publicado em 2006

Metabolic map and bioactivation of the anti-tumour drug noscapine

Por Fang, Zhong-Ze, Krausz, Kristopher W, Li, Fei, Cheng, Jie, Tanaka, Naoki, Gonzalez, Frank J
Publicado em 2012

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity

Por Bi, Huichang, Li, Fei, Krausz, Kristopher W., Qu, Aijuan, Johnson, Caroline H., Gonzalez, Frank J.
Publicado em 2013

Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair

Por Manna, Soumen K., Krausz, Kristopher W., Bonzo, Jessica A., Idle, Jeffrey R., Gonzalez, Frank J.
Publicado em 2013

Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity

Por Liu, Aiming, Krausz, Kristopher W., Fang, Zhong-Ze, Brocker, Chad, Qu, Aijuan, Gonzalez, Frank J.
Publicado no Arch Toxicol (2014)

Urinary metabolites and antioxidant products of exogenous melatonin in the mouse

Por Ma, Xiaochao, Idle, Jeffrey R., Krausz, Kristopher W., Tan, Dun-Xian, Ceraulo, Leopoldo, Gonzalez, Frank J.
Publicado em 2006