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Role of Pregnane X Receptor in Control of All-Trans Retinoic Acid (ATRA) Metabolism and Its Potential Contribution to ATRA Resistance

Although all-trans-retinoic acid (ATRA) is an effective treatment for acute promyelocytic leukemia and several solid tumors, its use is limited by resistance due to increased metabolism. The most studied mechanism for ATRA resistance is the autoinduced metabolism regulated by the retinoic acid recep...

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Detalhes bibliográficos
Main Authors: Wang, Ting, Ma, Xiaochao, Krausz, Kristopher W., Idle, Jeffrey R., Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268525/
https://ncbi.nlm.nih.gov/pubmed/17962516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.131045
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