PPARα-dependent Induction of Uncoupling Protein 2 Protects Against Acetaminophen-Induced Liver Toxicity

Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis. Activation of the peroxisome proliferator-activated receptor α (PPARα), a member of the nuclear...

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Detaylı Bibliyografya
Asıl Yazarlar: Patterson, Andrew D., Shah, Yatrik M., Matsubara, Tsutomu, Krausz, Kristopher W., Gonzalez, Frank J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378765/
https://ncbi.nlm.nih.gov/pubmed/22318764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25645
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