PPARα-Dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells

Peroxisome proliferator–activated receptor-α (PPARα) mediates the diverse biological effects of peroxisome proliferator (PP) chemicals, including fatty acid catabolism, hepatomegaly, hepatocyte proliferation, and hepatocarcinogenesis in rodents. However, transgenic mice expressing a constitutively a...

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Bibliographic Details
Main Authors: Qu, Aijuan, Shah, Yatrik M., Matsubara, Tsutomu, Yang, Qian, Gonzalez, Frank J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Carcinogenicity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984533/
https://ncbi.nlm.nih.gov/pubmed/20813756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq259
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