Carregant...

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-induced Hepatotoxicity

Metabolic bioactivation, glutathione depletion and covalent binding are the early hallmark events after acetaminophen (APAP) overdose. However, the subsequent metabolic consequences contributing to APAP-induced hepatic necrosis and apoptosis have not been fully elucidated. In this study, serum metab...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Chen, Chi, Krausz, Kristopher W., Shah, Yatrik M., Idle, Jeffrey R., Gonzalez, Frank J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670930/
https://ncbi.nlm.nih.gov/pubmed/19256530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800464q
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!