Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-induced Hepatotoxicity

Metabolic bioactivation, glutathione depletion and covalent binding are the early hallmark events after acetaminophen (APAP) overdose. However, the subsequent metabolic consequences contributing to APAP-induced hepatic necrosis and apoptosis have not been fully elucidated. In this study, serum metab...

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Main Authors: Chen, Chi, Krausz, Kristopher W., Shah, Yatrik M., Idle, Jeffrey R., Gonzalez, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670930/
https://ncbi.nlm.nih.gov/pubmed/19256530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800464q
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