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PPARα-dependent Induction of Uncoupling Protein 2 Protects Against Acetaminophen-Induced Liver Toxicity
Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis. Activation of the peroxisome proliferator-activated receptor α (PPARα), a member of the nuclear...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378765/ https://ncbi.nlm.nih.gov/pubmed/22318764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25645 |
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