Structure Activity Relationship Studies to Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1

Por Yuan, Ziyan, Kumar, Eric A., Kizhake, Smitha, Natarajan, Amarnath
Publicado em 2011

Computational and experimental studies of the interaction between phosphopeptides and the C-terminal domain of BRCA1

Por Anisimov, Victor M., Ziemys, Arturas, Kizhake, Smitha, Yuan, Ziyan, Natarajan, Amarnath, Cavasotto, Claudio N.
Publicado em 2011

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

Por You, Wanli, Huang, Yu-ming M., Kizhake, Smitha, Natarajan, Amarnath, Chang, Chia-en A.
Publicado no PLoS Comput Biol (2016)

Structural Characterization of BRCT-Tetrapeptide Binding Interactions

Por Joseph, Prem Raj B., Yuan, Ziyan, Kumar, Eric A., Lokesh, G. L., Kizhake, Smitha, Rajarathnam, Krishna, Natarajan, Amarnath
Publicado em 2010

Exploiting the P-1 Pocket of BRCT Domains Toward a Structure Guided Inhibitor Design

Por Yuan, Ziyan, Kumar, Eric A., Campbell, Stephen J., Palermo, Nicholas Y., Kizhake, Smitha, Glover, J. N. Mark, Natarajan, Amarnath
Publicado em 2011

The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides

Por Kumar, Eric A., Chen, Qianyi, Kizhake, Smitha, Kolar, Carol, Kang, Myungshim, Chang, Chia-en A., Borgstahl, Gloria E. O., Natarajan, Amarnath
Publicado em 2013

Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain

Por Kumar, Eric A., Yuan, Ziyan, Palermo, Nicholas Y., Dong, Lin, Ahmad, Gulzar, Lokesh, G.L., Kolar, Carol, Kizhake, Smitha, Borgstahl, Gloria E. O., Band, Hamid, Natarajan, Amarnath
Publicado em 2012

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure–Activity Relationship Study

Por Rana, Sandeep, Blowers, Elizabeth C., Tebbe, Calvin, Contreras, Jacob I., Radhakrishnan, Prakash, Kizhake, Smitha, Zhou, Tian, Rajule, Rajkumar N., Arnst, Jamie L., Munkarah, Adnan R., Rattan, Ramandeep, Natarajan, Amarnath
Publicado no J Med Chem (2016)

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

Por Contreras, Jacob I., Robb, Caroline M., King, Hannah M., Baxter, Jared, Crawford, Ayrianne J., Kour, Smit, Kizhake, Smitha, Sonawane, Yogesh A., Rana, Sandeep, Hollingsworth, Michael A., Luo, Xu, Natarajan, Amarnath
Publicado no ACS Chem Biol (2018)

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

Por Robb, Caroline M., Kour, Smit, Contreras, Jacob I., Agarwal, Ekta, Barger, Carter J., Rana, Sandeep, Sonawane, Yogesh, Neilsen, Beth K., Taylor, Margaret, Kizhake, Smitha, Thakare, Rhishikesh N., Chowdhury, Sanjib, Wang, Jing, Black, Jennifer D., Hollingsworth, Michael A., Brattain, Michael G., Natarajan, Amarnath
Publicado no Oncotarget (2017)