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Structural Characterization of BRCT-Tetrapeptide Binding Interactions
BRCT(BRCA1) plays a major role in DNA repair pathway, and does so by recognizing the conserved sequence pSXXF in its target proteins. Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity. Here, we have characterized the binding interactions of pSXXF tet...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834807/ https://ncbi.nlm.nih.gov/pubmed/20122900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.01.098 |
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