Exploiting the P-1 Pocket of BRCT Domains Toward a Structure Guided Inhibitor Design

[Image: see text] Breast cancer gene 1 carboxy terminus (BRCT) domains are found in a number of proteins that are important for DNA damage response (DDR). The BRCT domains bind phosphorylated proteins, and these protein–protein interactions are essential for DDR and DNA repair. High affinity domain...

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Detalhes bibliográficos
Main Authors: Yuan, Ziyan, Kumar, Eric A., Campbell, Stephen J., Palermo, Nicholas Y., Kizhake, Smitha, Glover, J. N. Mark, Natarajan, Amarnath
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201719/
https://ncbi.nlm.nih.gov/pubmed/22046493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200147a
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