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Structure Activity Relationship Studies to Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1

The carboxy terminal BRCT domains of the breast cancer susceptibility gene 1 (BRCA1) bind to a plethora of phosphorylated proteins through a pSXXF consensus recognition motif. BRCT-protein binding regulates key cellular functions such as lipogenesis, cell-cycle checkpoint control and DNA damage resp...

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Detalhes bibliográficos
Main Authors: Yuan, Ziyan, Kumar, Eric A., Kizhake, Smitha, Natarajan, Amarnath
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117075/
https://ncbi.nlm.nih.gov/pubmed/21574625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1016413
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