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Structure Activity Relationship Studies to Probe the Phosphoprotein Binding Site on the Carboxy Terminal Domains of the Breast Cancer Susceptibility Gene 1
The carboxy terminal BRCT domains of the breast cancer susceptibility gene 1 (BRCA1) bind to a plethora of phosphorylated proteins through a pSXXF consensus recognition motif. BRCT-protein binding regulates key cellular functions such as lipogenesis, cell-cycle checkpoint control and DNA damage resp...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117075/ https://ncbi.nlm.nih.gov/pubmed/21574625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1016413 |
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