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Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain
We describe truncation and SAR studies to identify a pentapeptide that binds Cbl tyrosine kinase binding domain with a higher affinity than the parental peptide. The pentapeptide has an alternate binding mode that allows occupancy of a previously uncharacterized groove. A peptide library was used to...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325325/ https://ncbi.nlm.nih.gov/pubmed/22394513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300078z |
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