Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

The study presented here provides a framework for the discovery of unique inhibitor combinations that target the apoptosis network for cancer therapy. A pair of doxycycline (Dox) -inducible cell lines that specifically report on the ability of an inhibitor to induce apoptosis either by targeting the...

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Publicado en:ACS Chem Biol
Main Authors: Contreras, Jacob I., Robb, Caroline M., King, Hannah M., Baxter, Jared, Crawford, Ayrianne J., Kour, Smit, Kizhake, Smitha, Sonawane, Yogesh A., Rana, Sandeep, Hollingsworth, Michael A., Luo, Xu, Natarajan, Amarnath
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119178/
https://ncbi.nlm.nih.gov/pubmed/29608269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00077
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