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Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)
Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK) family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously expressed and has been shown to contribute to a variety of malignancies such as pancreatic, prostate and breast canc...
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| Gepubliceerd in: | Chem Commun (Camb) |
|---|---|
| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555382/ https://ncbi.nlm.nih.gov/pubmed/28636052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc03879h |
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