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Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy
We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution in the hydrophobic pocket and analog...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295223/ https://ncbi.nlm.nih.gov/pubmed/30343954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.020 |
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