Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to Venetoclax

Cyclin-dependent kinase 9 (CDK9) is a member of the cyclin-dependent kinase (CDK) family which is involved in transcriptional regulation of several genes, including the oncogene Myc, and is a validated target for pancreatic cancer. Here we report the development of an aminopyrazole based proteolysis...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: King, Hannah M., Rana, Sandeep, Kubica, Sydney P., Mallareddy, Jayapal Reddy, Kizhake, Smitha, Ezell, Edward L., Zahid, Muhammad, Naldrett, Michael J., Alvarez, Sophie, Law, Henry C-H, Woods, Nicholas T., Natarajan, Amarnath
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187316/
https://ncbi.nlm.nih.gov/pubmed/33895280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.128061
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