Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

door Kasembeli, Moses M., Bharadwaj, Uddalak, Robinson, Prema, Tweardy, David J.
Gepubliceerd in Int J Mol Sci (2018)

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

door Bharadwaj, Uddalak, Kasembeli, Moses M., Robinson, Prema, Tweardy, David J.
Gepubliceerd in Pharmacol Rev (2020)

Contribution of chaperones to STAT pathway signaling

door Bocchini, Claire E, Kasembeli, Moses M, Roh, Soung-Hun, Tweardy, David J
Gepubliceerd in JAKSTAT (2014)

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

door Xu, Xuejun, Kasembeli, Moses M., Jiang, Xueqing, Tweardy, Benjamin J., Tweardy, David J.
Gepubliceerd in 2009

Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions

door Roh, Soung-Hun, Kasembeli, Moses M., Galaz-Montoya, Jesús G., Chiu, Wah, Tweardy, David J.
Gepubliceerd in Biophys J (2016)

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

door Bharadwaj, Uddalak, Kasembeli, Moses M., Eckols, T. Kris, Kolosov, Mikhail, Lang, Paul, Christensen, Kurt, Edwards, Dean P., Tweardy, David J.
Gepubliceerd in Cancers (Basel) (2014)

SMALL-MOLECULE TARGETING OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT) 3 TO TREAT NON-SMALL CELL LUNG CANCER()

door Lewis, Katherine M., Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M., Fridley, Colleen, Siller, Ricardo, Tweardy, David J.
Gepubliceerd in Lung Cancer (2015)

Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease

door Zhang, Liping, Wang, Ying, Dong, Yanlan, Chen, Zihong, Eckols, Thomas K., Kasembeli, Moses M., Tweardy, David J., Mitch, William E.
Gepubliceerd in Am J Physiol Renal Physiol (2020)

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

door Bocchini, Claire E., Nahmod, Karen, Katsonis, Panagiotis, Kim, Sang, Kasembeli, Moses M., Freeman, Alexandra, Lichtarge, Olivier, Makedonas, George, Tweardy, David J.
Gepubliceerd in Blood (2016)

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

door Bharadwaj, Uddalak, Eckols, T. Kris, Xu, Xuejun, Kasembeli, Moses M., Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y., Tweardy, David J.
Gepubliceerd in Oncotarget (2016)

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

door Bharadwaj, Uddalak, Eckols, T. Kris, Xu, Xuejun, Kasembeli, Moses M., Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y., Tweardy, David J.
Gepubliceerd in Oncotarget (2019)

Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity

door Minus, Matthew B., Liu, Wei, Vohidov, Farrukh, Kasembeli, Moses M., Long, Xin, Krueger, Michael, Stevens, Alexandra, Kolosov, Mikhail I., Tweardy, David J., Sison, Edward Allen R., Redell, Michele S., Ball, Zachary T.
Gepubliceerd in Angew Chem Int Ed Engl (2015)

Novel STAT3 Small-Molecule Inhibitors Identified by Structure-Based Virtual Ligand Screening Incorporating SH2 Domain Flexibility

door Kong, Ren, Bharadwaj, Uddalak, Eckols, T Kris, Kolosov, Mikhail, Wu, Haoyi, Cruz-Pavlovich, Francisco J. Santa, Shaw, Alison, Ifelayo, Oluwatomilona I., Zhao, Hong, Kasembeli, Moses M., Wong, Stephen T.C., Tweardy, David J
Gepubliceerd in Pharmacol Res (2021)

Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors

door Minus, Matthew B., Wang, Haopei, Munoz, Jaime O., Stevens, Alexandra M., Mangubat-Medina, Alicia E., Krueger, Michael J., Liu, Wei, Kasembeli, Moses M., Cooper, Julian C., Kolosov, Mikhail I., Tweardy, David J., Redell, Michele S., Ball, Zachary T.
Gepubliceerd in Org Biomol Chem (2020)

DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER

door Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M., Adam, Abel, Torres, David, Zhang, Xiaomei, Dobrolecki, Lacey E., Wei, Wei, Lewis, Michael T., Dave, Bhuvanesh, Chang, Jenny C., Landis, Melissa D., Creighton, Chad J., Mancini, Michael A., Tweardy, David J.
Gepubliceerd in 2014