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Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer and activator of transcription (STAT)3 was the focus of intense research into understanding the mammalian response to injury, particularly the acute-phase response. Although known to be essential for liver pro...

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Detalhes bibliográficos
Publicado no:Pharmacol Rev
Main Authors: Bharadwaj, Uddalak, Kasembeli, Moses M., Robinson, Prema, Tweardy, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300325/
https://ncbi.nlm.nih.gov/pubmed/32198236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.119.018440
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