Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity

Nearly 40% of children with acute myeloid leukemia (AML) suffer relapse due to chemoresistance, often involving upregulation of the oncoprotein STAT3 (signal transducer and activator of transcription 3). In this paper, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-...

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Publicado no:Angew Chem Int Ed Engl
Main Authors: Minus, Matthew B., Liu, Wei, Vohidov, Farrukh, Kasembeli, Moses M., Long, Xin, Krueger, Michael, Stevens, Alexandra, Kolosov, Mikhail I., Tweardy, David J., Sison, Edward Allen R., Redell, Michele S., Ball, Zachary T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041597/
https://ncbi.nlm.nih.gov/pubmed/26480340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506889
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