DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER

Signal transducer and activator of transcription (STAT) 3 regulates many cardinal features of cancer including cancer cell growth, apoptosis resistance, DNA damage response, metastasis, immune escape, tumor angiogenesis, the Warburg effect, and oncogene addiction and has been validated as a drug tar...

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Bibliographic Details
Main Authors: Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M., Adam, Abel, Torres, David, Zhang, Xiaomei, Dobrolecki, Lacey E., Wei, Wei, Lewis, Michael T., Dave, Bhuvanesh, Chang, Jenny C., Landis, Melissa D., Creighton, Chad J., Mancini, Michael A., Tweardy, David J.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182178/
https://ncbi.nlm.nih.gov/pubmed/24681959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.72
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