DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER

Signal transducer and activator of transcription (STAT) 3 regulates many cardinal features of cancer including cancer cell growth, apoptosis resistance, DNA damage response, metastasis, immune escape, tumor angiogenesis, the Warburg effect, and oncogene addiction and has been validated as a drug tar...

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Main Authors: Bharadwaj, Uddalak, Eckols, T. Kris, Kolosov, Mikhail, Kasembeli, Moses M., Adam, Abel, Torres, David, Zhang, Xiaomei, Dobrolecki, Lacey E., Wei, Wei, Lewis, Michael T., Dave, Bhuvanesh, Chang, Jenny C., Landis, Melissa D., Creighton, Chad J., Mancini, Michael A., Tweardy, David J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182178/
https://ncbi.nlm.nih.gov/pubmed/24681959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.72
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