Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

While STAT3 has been validated as a target for treatment of many cancers, including head and neck squamous cell carcinoma (HNSCC), a STAT3 inhibitor is yet to enter the clinic. We used the scaffold of C188, a small-molecule STAT3 inhibitor previously identified by us, in a hit-to-lead program to ide...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bharadwaj, Uddalak, Eckols, T. Kris, Xu, Xuejun, Kasembeli, Moses M., Chen, Yunyun, Adachi, Makoto, Song, Yongcheng, Mo, Qianxing, Lai, Stephen Y., Tweardy, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041982/
https://ncbi.nlm.nih.gov/pubmed/27027445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8368
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