Novel STAT3 Small-Molecule Inhibitors Identified by Structure-Based Virtual Ligand Screening Incorporating SH2 Domain Flexibility

Efforts to develop STAT3 inhibitors have focused on its SH2 domain starting with short phosphotyrosylated peptides based on STAT3 binding motifs, e.g. pY(905)LPQTV within gp130. Despite binding to STAT3 with high affinity, issues regarding stability, bioavailability, and membrane permeability of the...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Pharmacol Res
Главные авторы: Kong, Ren, Bharadwaj, Uddalak, Eckols, T Kris, Kolosov, Mikhail, Wu, Haoyi, Cruz-Pavlovich, Francisco J. Santa, Shaw, Alison, Ifelayo, Oluwatomilona I., Zhao, Hong, Kasembeli, Moses M., Wong, Stephen T.C., Tweardy, David J
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217378/
https://ncbi.nlm.nih.gov/pubmed/33932608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2021.105637
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы