Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients: A Novel Tool to Model the Pathogenesis of Cystic Kidney Disease

por Hofherr, Alexis, Köttgen, Michael
Publicado 2013

Nobel Prize 2020 in Chemistry honors CRISPR: a tool for rewriting the code of life

por Westermann, Lukas, Neubauer, Björn, Köttgen, Michael
Publicado en Pflugers Arch (2020)

Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition

por Hofherr, Alexis, Wagner, Claudius J., Watnick, Terry, Köttgen, Michael
Publicado en Kidney Int (2016)

N-Glycosylation Determines the Abundance of the Transient Receptor Potential Channel TRPP2

por Hofherr, Alexis, Wagner, Claudius, Fedeles, Sorin, Somlo, Stefan, Köttgen, Michael
Publicado 2014

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

por Woodward, Owen M., Köttgen, Anna, Coresh, Josef, Boerwinkle, Eric, Guggino, William B., Köttgen, Michael
Publicado 2009

Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels

por Köttgen, Michael, Hofherr, Alexis, Li, Weizhe, Chu, Kristy, Cook, Stacey, Montell, Craig, Watnick, Terry
Publicado 2011

P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

por Köttgen, Michael, Löffler, Thomas, Jacobi, Christoph, Nitschke, Roland, Pavenstädt, Hermann, Schreiber, Rainer, Frische, Sebastian, Nielsen, Søren, Leipziger, Jens
Publicado 2003

TRPP2 channels regulate apoptosis through the Ca(2+) concentration in the endoplasmic reticulum

por Wegierski, Tomasz, Steffl, Daniel, Kopp, Christoph, Tauber, Robert, Buchholz, Björn, Nitschke, Roland, Kuehn, E Wolfgang, Walz, Gerd, Köttgen, Michael
Publicado 2009

Efficient genome editing of differentiated renal epithelial cells

por Hofherr, Alexis, Busch, Tilman, Huber, Nora, Nold, Andreas, Bohn, Albert, Viau, Amandine, Bienaimé, Frank, Kuehn, E. Wolfgang, Arnold, Sebastian J., Köttgen, Michael
Publicado en Pflugers Arch (2016)

Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia

por Friedrich, Sebastian, Müller, Hannah, Riesterer, Caroline, Schüller, Hannah, Friedrich, Katja, Wörner, Carlotta Leonie, Busch, Tilman, Viau, Amandine, Kuehn, E. Wolfgang, Köttgen, Michael, Hofherr, Alexis
Publicado en Sci Rep (2021)

Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

por Woodward, Owen M., Tukaye, Deepali N., Cui, Jinming, Greenwell, Patrick, Constantoulakis, Leeza M., Parker, Benjamin S., Rao, Anjana, Köttgen, Michael, Maloney, Peter C., Guggino, William B.
Publicado 2013

Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells

por Fixemer, Jonas, Hummel, Jonas F., Arnold, Frederic, Klose, Christoph S. N., Hofherr, Alexis, Weissert, Kristoffer, Kögl, Tamara, Köttgen, Michael, Arnold, Sebastian J., Aichele, Peter, Tanriver, Yakup
Publicado en PLoS Pathog (2020)

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

por Schermer, Bernhard, Höpker, Katja, Omran, Heymut, Ghenoiu, Cristina, Fliegauf, Manfred, Fekete, Andrea, Horvath, Judit, Köttgen, Michael, Hackl, Matthias, Zschiedrich, Stefan, Huber, Tobias B, Kramer-Zucker, Albrecht, Zentgraf, Hanswalter, Blaukat, Andree, Walz, Gerd, Benzing, Thomas
Publicado 2005

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

por Köttgen, Michael, Benzing, Thomas, Simmen, Thomas, Tauber, Robert, Buchholz, Björn, Feliciangeli, Sylvain, Huber, Tobias B, Schermer, Bernhard, Kramer-Zucker, Albrecht, Höpker, Katja, Simmen, Katia Carmine, Tschucke, Christoph Carl, Sandford, Richard, Kim, Emily, Thomas, Gary, Walz, Gerd
Publicado 2005

Primary cilia regulate mTORC1 activity and cell size through Lkb1

por Boehlke, Christopher, Kotsis, Fruzsina, Patel, Vishal, Braeg, Simone, Voelker, Henriette, Bredt, Saskia, Beyer, Theresa, Janusch, Heike, Hamann, Christoph, Gödel, Markus, Müller, Klaus, Herbst, Martin, Hornung, Miriam, Doerken, Mara, Köttgen, Michael, Nitschke, Roland, Igarashi, Peter, Walz, Gerd, Kuehn, E. Wolfgang
Publicado 2010

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism

por Hofherr, Alexis, Seger, Claudia, Fitzpatrick, Fiona, Busch, Tilman, Michel, Elisabeth, Luan, Jingting, Osterried, Lea, Linden, Frieder, Kramer-Zucker, Albrecht, Wakimoto, Barbara, Schütze, Conny, Wiedemann, Nils, Artati, Anna, Adamski, Jerzy, Walz, Gerd, Kunji, Edmund R. S., Montell, Craig, Watnick, Terry, Köttgen, Michael
Publicado en PLoS Biol (2018)

TRPP2 and TRPV4 form a polymodal sensory channel complex

por Köttgen, Michael, Buchholz, Björn, Garcia-Gonzalez, Miguel A., Kotsis, Fruzsina, Fu, Xiao, Doerken, Mara, Boehlke, Christopher, Steffl, Daniel, Tauber, Robert, Wegierski, Tomasz, Nitschke, Roland, Suzuki, Makoto, Kramer-Zucker, Albrecht, Germino, Gregory G., Watnick, Terry, Prenen, Jean, Nilius, Bernd, Kuehn, E. Wolfgang, Walz, Gerd
Publicado 2008

Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

por Schlosser, Pascal, Li, Yong, Sekula, Peggy, Raffler, Johannes, Grundner-Culemann, Franziska, Pietzner, Maik, Cheng, Yurong, Wuttke, Matthias, Steinbrenner, Inga, Schultheiss, Ulla T., Kotsis, Fruzsina, Kacprowski, Tim, Forer, Lukas, Hausknecht, Birgit, Ekici, Arif B., Nauck, Matthias, Völker, Uwe, Walz, Gerd, Oefner, Peter J., Kronenberg, Florian, Mohney, Robert P., Köttgen, Michael, Suhre, Karsten, Eckardt, Kai-Uwe, Kastenmüller, Gabi, Köttgen, Anna
Publicado en Nat Genet (2020)

Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

por Viau, Amandine, Bienaimé, Frank, Lukas, Kamile, Todkar, Abhijeet P, Knoll, Manuel, Yakulov, Toma A, Hofherr, Alexis, Kretz, Oliver, Helmstädter, Martin, Reichardt, Wilfried, Braeg, Simone, Aschman, Tom, Merkle, Annette, Pfeifer, Dietmar, Dumit, Verónica I, Gubler, Marie‐Claire, Nitschke, Roland, Huber, Tobias B, Terzi, Fabiola, Dengjel, Jörn, Grahammer, Florian, Köttgen, Michael, Busch, Hauke, Boerries, Melanie, Walz, Gerd, Triantafyllopoulou, Antigoni, Kuehn, E Wolfgang
Publicado en EMBO J (2018)

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

por Tin, Adrienne, Woodward, Owen M., Kao, Wen Hong Linda, Liu, Ching-Ti, Lu, Xiaoning, Nalls, Michael A., Shriner, Daniel, Semmo, Mariam, Akylbekova, Ermeg L., Wyatt, Sharon B., Hwang, Shih-Jen, Yang, Qiong, Zonderman, Alan B., Adeyemo, Adebowale A., Palmer, Cameron, Meng, Yan, Reilly, Muredach, Shlipak, Michael G., Siscovick, David, Evans, Michele K., Rotimi, Charles N., Flessner, Michael F., Köttgen, Michael, Cupples, L. Adrienne, Fox, Caroline S., Köttgen, Anna
Publicado 2011