P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

Extracellular nucleotides are important regulators of epithelial ion transport. Here we investigated nucleotide-mediated effects on colonic NaCl secretion and the signal transduction mechanisms involved. Basolateral UDP induced a sustained activation of Cl(–) secretion, which was completely inhibite...

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Detalhes bibliográficos
Main Authors: Köttgen, Michael, Löffler, Thomas, Jacobi, Christoph, Nitschke, Roland, Pavenstädt, Hermann, Schreiber, Rainer, Frische, Sebastian, Nielsen, Søren, Leipziger, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151859/
https://ncbi.nlm.nih.gov/pubmed/12569163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316711
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