P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport

Extracellular nucleotides are important regulators of epithelial ion transport. Here we investigated nucleotide-mediated effects on colonic NaCl secretion and the signal transduction mechanisms involved. Basolateral UDP induced a sustained activation of Cl(–) secretion, which was completely inhibite...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Köttgen, Michael, Löffler, Thomas, Jacobi, Christoph, Nitschke, Roland, Pavenstädt, Hermann, Schreiber, Rainer, Frische, Sebastian, Nielsen, Søren, Leipziger, Jens
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2003
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151859/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12569163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16711
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