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Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal disease. The molecular pathogenesis of ADPKD is not completely known and there is no approved therapy. To date, there is limited knowledge concerning the molecular consequences of specific dise...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Hofherr, Alexis, Wagner, Claudius J., Watnick, Terry, Köttgen, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801696/
https://ncbi.nlm.nih.gov/pubmed/26924047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2015.11.015
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