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INHIBITION OF HISTONE DEACETYLASE 6 ACTIVITY REDUCES CYST GROWTH IN POLYCYSTIC KIDNEY DISEASE

Abnormal proliferation of cyst-lining epithelium and increased intra-cystic fluid secretion via the cystic fibrosis transmembrane conductance regulator (CFTR) are thought to contribute to cyst growth in autosomal dominant polycystic kidney disease (ADPKD). Histone deacetylase 6 (HDAC6) expression an...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Cebotaru, Liudmila, Liu, Qiangni, Yanda, Murali, Boinot, Clement, Outeda, Patricia, Huso, David L., Watnick, Terry, Guggino, William B., Cebotaru, Valeriu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912414/
https://ncbi.nlm.nih.gov/pubmed/27165822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.01.026
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