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N-Glycosylation Determines the Abundance of the Transient Receptor Potential Channel TRPP2

Glycosylation plays a critical role in the biogenesis and function of membrane proteins. Transient receptor potential channel TRPP2 is a nonselective cation channel that is mutated in autosomal dominant polycystic kidney disease. TRPP2 has been shown to be heavily N-glycosylated, but the glycosylati...

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Autori principali: Hofherr, Alexis, Wagner, Claudius, Fedeles, Sorin, Somlo, Stefan, Köttgen, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031537/
https://ncbi.nlm.nih.gov/pubmed/24719335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562264
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