Cleavage of IgGs by proteases associated with invasive diseases: An evasion tactic against host immunity?

od Brezski, Randall J, Jordan, Robert E
Wydane 2010

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

od Zhang, Ningyan, Jordan, Robert E., An, Zhiqiang
Wydane w Oncoimmunology (2015)

The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

od Brezski, Randall J., Knight, David M., Jordan, Robert E.
Wydane w ScientificWorldJournal (2011)

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

od Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Wydane 2011

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

od Jordan, Robert E., Fan, Xuejun, Salazar, Georgina, Zhang, Ningyan, An, Zhiqiang
Wydane w Oncoimmunology (2018)

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

od Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Wydane w Breast Cancer Res (2018)

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

od Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Wydane w MAbs (2015)

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

od Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Wydane 2012

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

od Brezski, Randall J., Vafa, Omid, Petrone, Diane, Tam, Susan H., Powers, Gordon, Ryan, Mary H., Luongo, Jennifer L., Oberholtzer, Allison, Knight, David M., Jordan, Robert E.
Wydane 2009

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

od Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, Robert E
Wydane w MAbs (2014)

Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions

od Kinder, Michelle, Greenplate, Allison R., Grugan, Katharine D., Soring, Keri L., Heeringa, Katharine A., McCarthy, Stephen G., Bannish, Gregory, Perpetua, Meredith, Lynch, Frank, Jordan, Robert E., Strohl, William R., Brezski, Randall J.
Wydane 2013