Cleavage of IgGs by proteases associated with invasive diseases: An evasion tactic against host immunity?

le Brezski, Randall J, Jordan, Robert E
Foilsithe 2010

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function

le Zhang, Ningyan, Jordan, Robert E., An, Zhiqiang
Foilsithe in Oncoimmunology (2015)

The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

le Brezski, Randall J., Knight, David M., Jordan, Robert E.
Foilsithe in ScientificWorldJournal (2011)

The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge

le Brezski, Randall J, Oberholtzer, Allison, Strake, Brandy, Jordan, Robert E
Foilsithe 2011

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy

le Jordan, Robert E., Fan, Xuejun, Salazar, Georgina, Zhang, Ningyan, An, Zhiqiang
Foilsithe in Oncoimmunology (2018)

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

le Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Foilsithe in Breast Cancer Res (2018)

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

le Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Foilsithe in MAbs (2015)

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

le Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Foilsithe 2012

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

le Brezski, Randall J., Vafa, Omid, Petrone, Diane, Tam, Susan H., Powers, Gordon, Ryan, Mary H., Luongo, Jennifer L., Oberholtzer, Allison, Knight, David M., Jordan, Robert E.
Foilsithe 2009

A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo

le Brezski, Randall J, Kinder, Michelle, Grugan, Katharine D, Soring, Keri L, Carton, Jill, Greenplate, Allison R, Petley, Theodore, Capaldi, Dorie, Brosnan, Kerry, Emmell, Eva, Watson, Sharon, Jordan, Robert E
Foilsithe in MAbs (2014)

Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions

le Kinder, Michelle, Greenplate, Allison R., Grugan, Katharine D., Soring, Keri L., Heeringa, Katharine A., McCarthy, Stephen G., Bannish, Gregory, Perpetua, Meredith, Lynch, Frank, Jordan, Robert E., Strohl, William R., Brezski, Randall J.
Foilsithe 2013