Next generation therapeutics for Alzheimer's disease

Autor Bredesen, Dale E, John, Varghese
Vydáno 2013

Importance of the Caspase Cleavage Site in Amyloid-β Protein Precursor

Autor Bredesen, Dale E., John, Varghese, Galvan, Veronica
Vydáno 2010

Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy

Autor Heinzelman, Pete, Bilousova, Tina, Campagna, Jesus, John, Varghese
Vydáno v Int J Alzheimers Dis (2016)

Ayurvedic medicinal plants for Alzheimer's disease: a review

Autor Rao, Rammohan V, Descamps, Olivier, John, Varghese, Bredesen, Dale E
Vydáno 2012

Structural and Functional Alterations in Amyloid-β Precursor Protein Induced by Amyloid-β Peptides

Autor Libeu, Clare Peters, Poksay, Karen S., John, Varghese, Bredesen, Dale E.
Vydáno 2011

C–O bond Formation in a Microfluidic Reactor: High Yield S(N)Ar Substitution of Heteroaryl Chlorides

Autor Alam, Mohammad Parvez, Jagodzinska, Barbara, Campagna, Jesus, Spilman, Patricia, John, Varghese
Vydáno v Tetrahedron Lett (2016)

Altering APP Proteolysis: Increasing sAPPalpha Production by Targeting Dimerization of the APP Ectodomain

Autor Libeu, Clare A. Peters, Descamps, Olivier, Zhang, Qiang, John, Varghese, Bredesen, Dale E.
Vydáno 2012

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans

Autor Maccecchini, Maria L, Chang, Mee Young, Pan, Catherine, John, Varghese, Zetterberg, Henrik, Greig, Nigel H
Vydáno 2012

Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery

Autor Subbiah, Naren, Campagna, Jesus, Spilman, Patricia, Alam, Mohammad Parvez, Sharma, Shivani, Hokugo, Akishige, Nishimura, Ichiro, John, Varghese
Vydáno v J Drug Deliv (2017)

Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor

Autor Duong, Alexander Tuan-Huy, Simmons, Bryan J., Alam, Mohammad Parvez, Campagna, Jesus, Garg, Neil K., John, Varghese
Vydáno v Tetrahedron Lett (2018)

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

Autor Shu, Cynthia, Parfenova, Liubov, Mokhonova, Ekaterina, Collado, Judd R., Damoiseaux, Robert, Campagna, Jesus, John, Varghese, Crosbie, Rachelle H.
Vydáno v Skelet Muscle (2020)

Paradoxical Effect of TrkA Inhibition in Alzheimer’s Disease Models

Autor Zhang, Qiang, Descamps, Olivier, Hart, Matthew J., Poksay, Karen S., Spilman, Patricia, Kane, Darci J., Gorostiza, Olivia, John, Varghese, Bredesen, Dale E.
Vydáno 2014

Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2

Autor Bilousova, Tina, Elias, Chris, Miyoshi, Emily, Alam, Mohammad-Parvez, Zhu, Chunni, Campagna, Jesus, Vadivel, Kanagasabai, Jagodzinska, Barbara, Gylys, Karen, John, Varghese
Vydáno v Biochem Biophys Res Commun (2018)

The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer’s model

Autor Spilman, Patricia, Descamps, Olivier, Gorostiza, Olivia, Peters-Libeu, Clare, Poksay, Karen S., Matalis, Alexander, Patent, Alexander, Rao, Rammohan, John, Varghese, Bredesen, Dale E.
Vydáno 2013

AβPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer’s Disease

Autor Descamps, Olivier, Spilman, Patricia, Zhang, Qiang, Libeu, Clare P., Poksay, Karen, Gorostiza, Olivia, Campagna, Jesus, Jagodzinska, Barbara, Bredesen, Dale E., John, Varghese
Vydáno 2013

A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

Autor Liu, Jian, Campagna, Jesus, John, Varghese, Damoiseaux, Robert, Mokhonova, Ekaterina, Becerra, Diana, Meng, Huan, McNally, Elizabeth M., Pyle, April D., Kramerova, Irina, Spencer, Melissa J.
Vydáno v Cell Rep Med (2020)

GoCoronaGo: Privacy Respecting Contact Tracing for COVID-19 Management

Autor Simmhan, Yogesh, Rambha, Tarun, Khochare, Aakash, Ramesh, Shriram, Baranawal, Animesh, George, John Varghese, Bhope, Rahul Atul, Namtirtha, Amrita, Sundararajan, Amritha, Bhargav, Sharath Suresh, Thakkar, Nihar, Kiran, Raj
Vydáno v J Indian Inst Sci (2020)

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

Autor Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Vydáno v Front Pharmacol (2017)

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Autor Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Vydáno v Mol Brain (2021)

Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Autor Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese
Vydáno v Mol Brain (2021)