AβPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer’s Disease

A systematic approach was used to identify AβPP-selective BACE inhibitors (ASBI) and to evaluate their in vivo ability to modulate AβPP processing selectively. We identified a bioflavonoid nutritional supplement as a molecular lead that acts as an ASBI in cell models, and show that increasing brain...

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Bibliographic Details
Main Authors: Descamps, Olivier, Spilman, Patricia, Zhang, Qiang, Libeu, Clare P., Poksay, Karen, Gorostiza, Olivia, Campagna, Jesus, Jagodzinska, Barbara, Bredesen, Dale E., John, Varghese
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971881/
https://ncbi.nlm.nih.gov/pubmed/23948888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-130578
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